In a recent eight week clinical study conducted at the University of Connecticut, participants achieved significant results when compared to the placebo in the following areas:

• Weight Loss (70% greater results than placebo test groups)
• Fat Loss (92% greater results than placebo test groups)
• Body Composition Enhancement (121% greater results than placebo test groups)
• Waist Circumference Reduction (62% greater results than placebo test groups)
  

Abstract

The influence of a proprietary blend of high viscosity polysaccharides and esterified fatty acids on adipocytokine and regional body composition responses to a weight loss program was examined. Twenty-two women (Supplement group (S) (n=11): age= 36.8±7.2 y; weight=87.4 ±6.1 kg; % body fat= 43.6±7.1); Placebo group (P) (n=11): age = 38.3±6.8 y; weight = 88.3±7.2 kg; % body fat=44.2±8.2) completed an 8-week placebo-controlled, double-blind study consisting of a caloric restricted diet and cardiovascular exercise. Body composition and serum insulin, leptin, and adiponectin were assessed at pre-, mid-, and post- intervention. From pre- to post- intervention, significant decreases (p<0.05) were observed for body weight (S: 87.4±6.1 to 78.2±3.4 kg; P: 88.3±7.2 to 82.9±4.1 kg) (p<0.05 S vs P), % body fat (S: 43.6±7.1 to 36.2±4.4; P: 44.3±8.2 to 40.9±4.3) (p<0.05 S vs P), leptin (S: 28.2±6.1 to 16.3±3.4 µg·ml-1: 29.3±9.1 to 19.7±3.3 µg·ml-1) (p<0.05 S vs P), and insulin (S: 7.2±2.2 to 5.4±2.4 mU·L-1; P: 7.7±2.2 to 5.2±2.7 mU·L-1). Serum adiponectin increased (p<0.05) (S: 12.2±3.1 to 26.2±3.4 µg·ml-1: 12.6±4.2 to 21.7±4.3 µg·ml-1) (p<0.05 for S vs P). Data indicated that supplementation with a proprietary blend of high viscosity polysaccharides and esterified fatty acids during an 8-week weight loss program exhibited favorable effects on adipocytokines and regional body composition.

Introduction

• Unsuccessful attempts to modulate human obesity have lead to many research attempts to understand the neurological and hormonal pathways regulating energy intake and energy expenditure
• Adipocytokines appear to play an important role in the connection between the brain, adipose tissue and other peripheral organs involved in the weight regulatory pathway
• Weight loss programs combining dietary and exercise lifestyle interventions behavior modification and medication appear to be more effective than any these strategies administered alone

Purpose

To determine the effects of a proprietary blend of high viscosity polysaccharides and esterified fatty acids supplementation when combined with an 8-week diet and exercise regimen in women who were overweight on adiposity and adipocytokines

Methods

Participants: 22 healthy women who were overweight Supplement Group (N= 11): Age: 36.8±7.2 y; Height: 163.8±9.1cm Placebo group (N= 11): Age: 38.3±6.8 y; Height: 162.7±9.3 cm

Exercise: 30-60 minutes, 4-5 days/week at 60-90% of max HR Cycling, walking, jogging

Diet: Moderately caloric restricted diet of self-selected commercially available foods in a free-living environment. Weekly nutritional counseling meetings led by a registered dietician.

Supplement: 3 capsules at the two largest meals each day (6 capsules per day) Supplement = 400 mg of high viscosity polysaccharides and Celadrin.

placebo = 400 mg of magnesium stearate per capsule)

Results

Body Mass

Body Mass (kg) during the 8-week weight loss intervention for the supplement and placebo groups. * = P < 0.05 from corresponding Week 0 value. † = P < 0.05 from corresponding Week 4 value. ‡ = P < 0.05 from corresponding Placebo Group value

Body Composition

Body Composition (% Body Fat) during the 8-week weight loss intervention for the supplement and placebo groups. * = P < 0.05 from corresponding Week 0 value. † = P <0.05 from corresponding Week 4 value. ‡ = P < 0.05 from corresponding Placebo Group value

Insulin

Circulating Insulin (mU/L) during the 8-week weight loss intervention for the supplement and placebo groups. * = P < 0.05 from corresponding Week 0 value. † = P < 0.05 from corresponding Week 4 value. ‡ = P < 0.05 from corresponding Placebo Group value

Adiponectin

Circulating Adiponectin (µg/ml) during the 8-week weight loss intervention for the supplement and placebo groups. * = P < 0.05 from corresponding Week 0 value. † = P < 0.05 from corresponding Week 4 value. ‡ = P < 0.05 from corresponding Placebo Group value

Leptin

Circulating Leptin (ng/ml) during the 8-week weight loss intervention for the supplement and placebo groups. * = P < 0.05 from corresponding Week 0 value. † = P < 0.05 from corresponding Week 4 value. ‡ = P < 0.05 from corresponding Placebo Group value

Waist Circumference

Waist Circumference (cm) changes during the 8-week weight loss intervention for the supplement and placebo groups. * = P < 0.05 from corresponding Week 0 value. † = P < 0.05 from corresponding Week 4 value. ‡ = P < 0.05 from corresponding Placebo Group value

Hip Circumference

Hip Circumference (cm) changes during the 8-week weight loss intervention for the supplement and placebo groups. * = P < 0.05 from corresponding Week 0 value. † = P < 0.05 from corresponding Week 4 value. ‡ = P < 0.05 from corresponding Placebo Group value

Thigh Circumference

Thigh Circumference (cm) changes during the 8-week weight loss intervention for the supplement and placebo groups. * = P < 0.05 from corresponding Week 0 value. † = P < 0.05 from corresponding Week 4 value. ‡ = P < 0.05 from corresponding Placebo Group value

Conclusion

Both groups of women in the 8-week weight loss program showed:

• Significant weight and fat loss
• Significant changes in circulating adipocytokine concentrations

Women receiving the soluble polysaccharide dietary supplement during the weight loss program showed:

• Greater weight loss
• Greater fat loss
• Greater effects on circulating adipocytokine concentrations